Characteristics of Lynch syndrome in 13 Hispanic Families

Background While the incidence of colorectal cancer is lower in Hispanics than in non-Hispanic Caucasians, it is the second most common cancer in this diverse ethnic population. Emerging data indicate hereditary colon cancer syndromes contribute to cancer burden regardless of race and ethnicity. These data derive from research and cohorts where Hispanics are underrepresented. Here we report on 14 individuals from 13 Hispanic families with Lynch syndrome. Methods After referral for cancer risk assessment, immunohistochemical staining was performed for the four MMR gene products and/or analysis of the appropriate gene(s) was initiated.